I just put these tires on my truck a couple days ago.
They fit perfect with the ready lift 2.4" kit (which actually turned out to be around 2.75"). With the tires and lift, the front wheel well height increased by about 4 inches. (Sorry for the vague measurement, I have them all written down at home).
As for rubbing issues.... I had the skid plate bent up below the sway bar just to be safe and I removed the little mud flaps in front of the tires. There was only one incident of rubbing when I was at full left lock and on a wierd angle, however they touched just enough to make a bit of noise without any sort of damage. (Please don't hold me to this because I've only had them 3 days with limited driving time.)
The spacer made the ride a tad bit more firm, but i'm super picky and notice stupid things like that. On that note, the toyo's seem to feel much softer than the crappy BFG's that came with the TRD package and therefore even out any change in ride. They are also quieter on the freeway and around town than the old ones.
In my opinion these tires make the truck perfectly proportional and seem to be the best choice, especially considering the minimal increase in width.
Hope this helps.
BTW... It looks way better in person