If its mostly flat, Id say go for it, but do not be surprise when you got to up shift and do WOT at red line to maintain 30mph on a grade.
Here is my taco on route to chapmanville, wva from richmond, va. You can hear the supercharger whine in the background. I am unloaded going to the truck show I won 2nd place. No problem maintaining hwy speeds, however at times it jumped to 2nd gear.
YouTube - supercharger full boost
YouTube - trd supercharger