I'm still using my Tundra to haul my big 5er on at least one long trip a year (1,200 miles round trip) and few shorter trips for camping. Towing a 5th wheel is much more comfortable than a travel trailer. You still know it's there, but there is more positive control, less sway with crosswinds or passing trucks, and you get more trailer with the over-bed bedroom for the overall length you have behind you.
You also don't need to worry about weight distributing hitches, and you can turn and back at better angles. Not that travel trailers are bad, just 5th is better. Here's a thread on my towing experience last summer:
Tundra as Tow-Mobile: 1,200 miles, 12,000 lbs, 10 MPG