Scottie, I'm apologizing in advance

because I'm about to completely trash those tires but wanted to let you know it's nothing personal! So I'm sorry

. Here goes...
Cons-
Rub on the bumper, pinch weld, mud flap, frame, UCA.
Poor road handling except on glassy smooth pavement, same on the dirt.
Complete inability to perform at low pressure, offroad performance will be garbage.
Loss of acceleration from higher rotating mass (wide tire and big rim)
Pros-
Dude, they will look tight and hella tuff, bro

. All the flatbillers will love it :devil:.
Bottom Line-
These are show tires. They will do nothing well LOL!...they are meant to look really good and that's it. Out of the 17 available sizes only a half dozen are in the range of "good" for anything offroad, unless you need flotation tires. If you're using this as a show truck, the large rims and wide semi-aggressive tread will definately look good, but that's about all it will do. Even on the street, while that wide tire will corner well, the width will grab ruts, seams, edges and curbs with a quickness, and the tread pattern will prevent it from ever being a real street performer. If somebody recommended these tires on the grounds they're real offroad performers in that size, they're mistaken

. They do come in good sizes for running around offroad...but that's not one of them

and it'll be a pain to fit.
Now I've totally hosed on those tires

...like I said nothing personal!...here's how you could fit them

.
Like jberry said, you'll need to mod a few things. It isn't the height, it's actually the width that will get you. If you run a uniball upper control arm AND a total of about 3"-3.5" backspacing (assuming you have the right rim width, probably 10" wide), you'll clear the upper control arm. I'm running 35x12.5R16 on 3" backspacing at 16x8 with uniballs and I have about an inch to the UCA. I think you could work it out with the right rims, or a wheel adapter. The right combination should also keep it off the frame.
It will still rub the front bumper--cut it or get something else up there--and the back of the wheel well. To run with 3" lift and clear these tires, you'll need 930 CV boots if you have 4x4, and to keep the ride comfortable you'll need longer shocks and uniball UCAs...a 3" spacer will ride like hell.
For the rear of the wheel well, you'll at least need to do what jberry did. If you plan to go offroad (not redlining through dirty puddles or dirt roads through the woods, but twisted gnarly offroad), you'll need to actually tub the wheel wells like I have. That's also when you'll find that width and rim size don't cut it offroad :devil:. Of course, with a tub job you'll be able to fit a taller tire as well...anyway...
Hope that helps, whatever you choose to do.
-Sean